Related Experiment Video
Updated: Jun 6, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
Clinicopathologic features of systemic ALK-negative anaplastic large cell lymphoma with TP53 deletion
Wei J Wang1, Guilin Tang1, L Jeffrey Medeiros1
1Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Objectives:
In this study, we illustrated the significance of TP53 deletion (D) in systemic ALK-negative anaplastic large cell lymphoma (ALCL), an area that remains unknown.
Methods:
We evaluated TP53-D by fluorescence in situ hybridization in 66 patients with systemic ALK-negative ALCL and compared the results with clinicopathologic features.
Results:
TP53-D was identified in 32 (48%) cases. Peripheral blood involvement occurred exclusively in the TP53-D group compared with the TP53-not deleted (ND) group (50% vs 0%, P = .01). TP53-D cases more frequently showed p53 overexpression by immunohistochemistry than TP53-ND cases (P = .03). Among the International Prognostic Index (IPI) score, TP53-D, DUSP22 rearrangement (DUSP22-R), and stem cell transplantation status, for the entire cohort, only a low IPI score (<3) was associated with superior overall survival (P = .04), while none of these factors affected progression-free survival (PFS). In TP53-ND patients, low IPI and DUSP22-R were associated with significantly longer PFS (P = .04 and P = .02); these associations were absent in TP53-D patients.
Conclusions:
TP53-D is common in systemic ALK-negative ALCL and is associated with leukemic disease and p53 overexpression. TP53-D did not directly affect survival, but it negated the favorable impact of low IPI and DUSP22-R on PFS, suggesting its potential value as an adverse prognostic marker.
Related Concept Videos
Abnormal Proliferation
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
The Intrinsic Apoptotic Pathway
