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Updated: Jul 9, 2026
17:13
Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
Published on: April 28, 2013
Cancer after renal transplantation
Brahm Vasudev1, Sundaram Hariharan
1Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Current Opinion in Nephrology and Hypertension
|December 20, 2007
Summary
Newer immunosuppressants like sirolimus and mycophenolate mofetil may reduce cancer risk after transplantation. Careful patient selection and monitoring are key to improving outcomes for transplant recipients.
Area of Science:
- Nephrology
- Oncology
- Immunology
Background:
- Increasing recipient age and improved transplant survival raise concerns about posttransplant cancer.
- Longer patient survival necessitates better understanding and management of posttransplant malignancies.
Purpose of the Study:
- To review current evidence on posttransplant cancer incidence and risk factors.
- To evaluate the role of immunosuppressive agents in posttransplant cancer development and management.
Main Methods:
- Review of recent clinical evidence and studies on immunosuppressive drugs.
- Analysis of data from transplant registries and clinical trials.
Main Results:
- Sirolimus is linked to lower rates of de-novo cancers and remission of specific skin cancers.
- Mycophenolate mofetil exhibits anti-proliferative and anti-tumor effects, reducing posttransplant lymphoproliferative disorder incidence.
Conclusions:
- Judicious use of newer immunosuppressants can potentially decrease posttransplant cancer incidence.
- Optimizing candidate selection, surveillance, and immunosuppression is crucial for improving outcomes.
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