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Longitudinal tracking of FTLD: toward developing clinical trial methodology

David S Knopman1, Bradley S Boeve, Richard J Caselli

  • 1Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA. knopman@mayo.edu

Alzheimer Disease and Associated Disorders
|December 20, 2007
PubMed

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...