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Related Experiment Videos

The reference method value.

C Franzini1

  • 1Laboratorio Centrale, Ospedale di Rho, Milano.

Annali Dell'Istituto Superiore Di Sanita
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Achieving accuracy in routine testing relies on a hierarchy of methods and traceable materials. Improving method commutability and reducing matrix sensitivity are key to reliable laboratory results.

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Area of Science:

  • Clinical diagnostics
  • Laboratory medicine
  • Analytical chemistry

Background:

  • Routine laboratory testing accuracy depends on a hierarchy of methods and traceable materials.
  • Matrix-sensitive methods, common in routine testing, can yield unreliable results with different materials like clinical specimens and reference materials.
  • Ensuring accuracy requires careful consideration of material commutability and method matrix sensitivity.

Purpose of the Study:

  • To explore the hierarchy of methods for achieving and controlling accuracy in routine laboratory testing.
  • To identify challenges in transferring accuracy and monitoring traceability using different materials.
  • To propose pathways for improving the reliability of routine testing results.

Main Methods:

  • Review of existing methods for accuracy transfer and traceability monitoring in laboratory testing.

Related Experiment Videos

  • Analysis of the impact of matrix-sensitive methods and non-commutable materials on result reliability.
  • Evaluation of the role of intermediate-level reference methods and clinical specimen comparisons.
  • Consideration of experimental designs for assigning system-specific values to non-commutable materials.

    • Main Results:

    • Unreliable results are frequent when matrix-sensitive routine methods are used with different materials (e.g., clinical specimens vs. reference materials).
    • Intermediate-level methods using clinical specimens can bridge accuracy gaps between different testing levels.
    • Non-commutable materials for calibration require system-specific values determined through appropriate experimental design and clinical specimen use.

    Conclusions:

    • Establishing networks of reference laboratories is a practical approach to implementing and sustaining accurate reference systems.
    • Future improvements should focus on reducing the matrix sensitivity of routine methods.
    • Increasing the commutability of reference materials is crucial for enhancing the accuracy of routine laboratory testing.