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Association between intussusception and tonsil disease in childhood
Hanne Vestergaard1, Tine Westergaard, Jan Wohlfahrt
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. hvs@ssi.dk
Epidemiology (Cambridge, Mass.)
|December 20, 2007
Summary
Children with intussusception face a higher risk of developing tonsil disease. This suggests a potential link between intussusception and a general tendency towards lymphoid hyperplasia.
Area of Science:
- Pediatric Gastroenterology
- Otolaryngology
- Immunology
Background:
- Intussusception is a leading cause of intestinal obstruction in children, but its origins are unclear.
- This study investigates a potential association between intussusception and subsequent tonsil disease.
Purpose of the Study:
- To determine if children diagnosed with intussusception have an increased risk of developing tonsil disease later in childhood.
- To explore the hypothesis that a tendency towards lymphoid hyperplasia may predispose children to intussusception.
Main Methods:
- A nationwide Danish cohort study included 2,018 children under 15 diagnosed with intussusception between 1977-2001.
- Follow-up data on tonsil disease were obtained from national patient and health security registries.
Main Results:
- 172 children developed tonsil disease post-intussusception.
- The risk of tonsil disease was 48% higher in children with intussusception compared to the general population.
- Increased risks were observed for acute tonsillitis, chronic tonsil disease, and tonsillectomy.
Conclusions:
- Intussusception is linked to a significantly increased risk of childhood tonsil disease.
- A predisposition to lymphoid hyperplasia might increase susceptibility to both intussusception and tonsil disease.
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