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Published on: June 29, 2019
Functional dyspepsia and nonerosive reflux disease: clinical interactions and their implications
John Keohane1, Eamonn M M Quigley
1Alimentary Pharmabiotic Centre, Department of Medicine, University College Cork, Cork, Ireland.
Abstract:
Functional dyspepsia or nonulcer dyspepsia, and nonerosive reflux disease (NERD) or endoscopy-negative reflux disease, are common reasons for referral to a gastroenterologist. Although there is much confusion with regard to definition, recent research would suggest that these 2 conditions are linked and may represent components in the spectrum of the same disease entity, in terms of both symptoms and pathophysiology. Several theories have been proposed regarding the etiology of these disorders, including acid exposure, visceral hypersensitivity, impaired fundal accommodation, delayed gastric emptying, and Helicobacter pylori infection.
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