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Visualization and Analysis of Pharyngeal Arch Arteries using Whole-mount Immunohistochemistry and 3D Reconstruction
Published on: March 31, 2020
[Pharyngitis in children]
1Service de microbiologie, CHI Créteil, 94010 Créteil. robert.cohen@wanadoo.fr
Insights
Antibiotic resistance necessitates a shift in pharyngitis care. Rapid diagnostic tests for Group A Streptococcus (GAS) enable targeted antibiotic use, reducing consumption while ensuring effective treatment for GAS infections.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Context:
- Pharyngitis management has evolved due to increasing antibiotic resistance.
- Traditional systematic antibiotic treatment for pharyngitis to prevent rheumatic fever is no longer sustainable.
- Clinical signs alone are unreliable for differentiating streptococcal from viral pharyngitis.
Purpose:
- To outline the updated strategy for pharyngitis management.
- To highlight the role of rapid diagnostic tests in guiding antibiotic decisions.
- To recommend appropriate antibiotic choices and durations for confirmed Group A Streptococcus (GAS) infections.
Summary:
- Group A Streptococcus (GAS) rapid diagnostic tests (RDTs) offer high sensitivity and specificity (>90% and >95%, respectively).
- Positive GAS RDTs warrant antibiotic treatment; negative RDTs indicate non-streptococcal pharyngitis, not requiring antibiotics.
- This approach is expected to reduce antibiotic consumption for pharyngitis by two-thirds, maintaining therapeutic benefits.
Impact:
- Significant reduction in overall antibiotic consumption for pharyngitis.
- Preservation of antibiotic efficacy by targeting treatment to necessary cases.
- Recommendations for beta-lactam antibiotics (e.g., amoxicillin) for short durations due to GAS resistance to macrolides.
Abstract:
The care strategy of pharyngitis has been changed dramatically these last years. Because of evolution of antibiotic resistance, the attitude which prevailed of the systematic treatment of pharyngitis in order to prevent a hypothetical acute rheumatic fever, could not persist. Discrimination between pharyngitis due to group A streptococcus (GAS) and nonstreptococcal pharyngitis (usually of viral causes) cannot be made in a reliable way by the clinical signs and symptoms, even if clinical scores are used. The free availability to practitioners of GAS rapid diagnostic tests, sensitive (>90%) and specific (>95%), changes the rule by simplifying it: pharyngitis with positive test must be treated with antibiotics, those with negative test should not be received such treatment. A reduction of two thirds of antibiotics consumption for pharyngitis can be expected, while maintaining the benefit (improvement of the clinical signs, reduction of contagiousness and the complications) for the patients for whom it is necessary. Because of GAS resistance to macrolides and the absence of resistance to beta-lactam antibiotics, a compound belonging of this last family should be prescribed and for a short treatment duration: amoxicillin (50 mg/kg/j, b.i.d for 6 days), cefpodoxime proxetil (8 mg/kg/j b.i.d for 5 days), cefuroxime axetil (30 mg/kg/j b.i.d for 4 days).
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