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Published on: September 19, 2019
[Child acute otitis media]
1Service de microbiologie, CHI Créteil, 94010 Créteil. robert.cohen@wanadoo.fr
Insights
Prevenar immunization and reduced antibiotic use in France decreased resistant pneumococci strains. Non-typable Haemophilus influenzae is now the primary cause of acute otitis media (AOM), presenting a new challenge.
Area of Science:
- Otolaryngology
- Pediatrics
- Infectious Diseases
Context:
- Acute otitis media (AOM) is a common pediatric complication of upper respiratory infections.
- AOM is a leading cause of bacterial infections and antibiotic prescriptions in children.
- France has observed shifts in AOM bacterial pathogens due to vaccination and antibiotic stewardship.
Purpose:
- To analyze the impact of Prevenar immunization and reduced antibiotic consumption on bacterial resistance patterns in AOM.
- To identify the predominant bacterial species causing AOM in the current French context.
- To review diagnostic criteria and current French antibiotic prescribing guidelines for purulent AOM.
Summary:
- Highly resistant pneumococcal strains significantly decreased following combined Prevenar immunization and reduced antibiotic use.
- Non-typable Haemophilus influenzae has emerged as the primary bacterial pathogen responsible for AOM.
- Beta-lactam resistance in H. influenzae, mediated by altered penicillin-binding proteins, is an emerging concern.
Impact:
- The study highlights a successful reduction in problematic pneumococcal resistance but identifies a new etiological challenge with H. influenzae.
- Updated understanding of AOM epidemiology is crucial for refining diagnostic and therapeutic strategies.
- Adherence to French guidelines for judicious antibiotic prescribing in AOM is emphasized to combat emerging resistance.
Abstract:
Most frequent complication of children upper respiratory tract infections, acute otitis media is the leading cause of bacterial infections and one of the leading causes of antibiotic prescriptions. Under the combined effect of Prevenar immunization and the reduction of the use of antibiotics in France, the highly resistant strains of pneumococci (those which posed therapeutic problems) decreased moreover of the three quarter. Non typable H. influenzae became the main bacteria responsible of AOM, and resistance to the beta-lactams by change of penicillin binding proteins is an emergent problem in France. The diagnosis of purulent OMA is based on a triad: recent onset functional (otalgia) and generals (fever) signs, middle ear effusion and tympanic membrane inflammation. The official French guidelines suggest prescribing antibiotics (amoxicillin-acid clavulanate-cefpodoxime proxetil) only for purulent acute otitis media diagnosed in an unquestionable way, systematically in the child of less than two years, only for the most symptomatic forms after this age, while making use of the history and the clinical and bacteriological correlations to choose antibiotic.
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