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High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection

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Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans.

Daniel A Athanazio¹, Everton F Silva, Cleiton S Santos

¹Gonçalo Moniz Research Centre, Oswaldo Cruz Foundation, Ministry of Health, Salvador, Brazil.

|December 21, 2007

Summary

This study shows that Wistar rats effectively model leptospirosis, with Leptospira interrogans persisting in kidneys for months. This rat model aids understanding leptospirosis pathogenesis and resistance mechanisms.

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Area of Science:

Infectious Diseases
Bacteriology
Animal Models

Background:

Leptospirosis pathogenesis remains poorly understood.
The experimental rat model offers a platform to study leptospiral dissemination and disease resistance.

Purpose of the Study:

To investigate leptospiral dissemination, renal colonization, and persistence in an experimental rat model.
To evaluate the suitability of Wistar rats for leptospirosis research.

Main Methods:

Wistar rats were infected with Leptospira interrogans serovar Copenhageni.
Leptospire detection utilized culture, silver staining, and immunofluorescence.
Colonization and dissemination kinetics were monitored over four months.

Main Results:

Leptospiral renal colonization occurred 7-9 days post-infection and persisted for four months in 50% of rats.
Peak leptospiral load was observed on day 5 post-infection.
Dense leptospiral aggregates persisted in renal tubules, with rapid clearance in other tissues.

Conclusions:

The Wistar rat model is suitable for studying leptospiral colonization mechanisms.
This model can advance understanding of resistance to severe leptospirosis.