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The Generation R Study Biobank: a resource for epidemiological studies in children and their parents

Vincent W V Jaddoe1, Rachel Bakker, Cock M van Duijn

  • 1The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl

European Journal of Epidemiology
|December 21, 2007
PubMed

Insights

The Generation R Study tracks 9,778 mothers and their children from fetal life to young adulthood. It collects biological samples and detailed data to understand environmental and genetic factors influencing growth and health.

Area of Science:

  • Epidemiology
  • Developmental Biology
  • Genetics

Background:

  • The Generation R Study is a population-based prospective cohort study.
  • It aims to identify early environmental and genetic causes of growth, development, and health.
  • The study enrolled 9,778 mothers from fetal life onwards.

Purpose of the Study:

  • To describe the collection, processing, and storage of biological specimens.
  • To highlight the unique resource for epidemiological research.
  • To facilitate studies on environmental exposures, genetic determinants, and their interactions.

Main Methods:

  • Prospective cohort design from fetal life to young adulthood.
  • Data collection through physical examinations, questionnaires, interviews, and ultrasound.
  • Collection of biological specimens including DNA, blood for phenotypes, and urine samples.

Main Results:

  • Detailed methods for biological specimen handling are presented.
  • Biological specimens are stored alongside phenotype measurements.
  • A unique resource for epidemiological studies is established.

Conclusions:

  • The Generation R Study provides a comprehensive dataset and biological resource.
  • It enables research into early life determinants of health and development.
  • Interactions between environmental and genetic factors can be investigated.

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