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Validation and quality control of protein microarray-based analytical methods.

Larry J Kricka1, Stephen R Master

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA. kricka@mail.med.upenn.edu

Molecular Biotechnology
|December 21, 2007
PubMed
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Protein microarray technology holds promise for clinical diagnostics. Implementing robust quality control is essential to ensure accurate results and reliable diagnostic or prognostic markers from these assays.

Area of Science:

  • Biotechnology
  • Laboratory Medicine

Background:

  • Protein microarray technology is primarily utilized in research settings.
  • It aids in identifying potential diagnostic and prognostic markers for future clinical use.

Purpose of the Study:

  • To survey strategies for assuring the analytical quality of protein microarray methods.
  • To highlight challenges in transitioning these assays to routine clinical practice.

Main Methods:

  • Review of quality control and assurance strategies for protein microarrays.
  • Identification of potential pitfalls in clinical implementation.

Main Results:

  • Quality control is crucial for obtaining high-quality data from protein microarrays.
  • Erroneous results due to poor quality control can obscure important diagnostic associations.

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Conclusions:

  • Appropriate quality control and assurance measures are vital for protein microarray assays.
  • These measures will enable protein microarray-based assays to benefit future laboratory medicine practices.