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Updated: Jul 9, 2026

Chromatographic Fingerprinting by Template Matching for Data Collected by Comprehensive Two-Dimensional Gas Chromatography
Published on: September 2, 2020
Multidimensional chromatography: validation and efficient fishing for biomarkers and fractions containing them using
Gerhard A Cumme1, Stefan Kreusch, Matthias Nagel
1Institute of Biochemistry I, Medical Faculty, Friedrich Schiller University, Jena, Germany.
Abstract:
2-D native LC yields thousands of fractions especially when applied to sera of different origin. Checking reproducibility of repeated separation of the same serum or searching for biomarker candidates and fractions containing them requires finding, selection, and comparison of interesting data subsets out of huge data volumes. An innovative software package is applied that markedly enhances simplicity, velocity, and reliability of (i) check of reproducibility of the separation method and (ii) analysis of proteomes pertaining to different disease states.
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