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Related Concept Videos

In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation
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Past and future evolution in colloidal drug delivery systems.

Ben J Boyd1

  • 1Department of Pharmaceutics, Victorian College of Pharmacy - Monash University, 381 Royal Pde, Parkville, VIC, 3052, Australia. ben.boyd@vcp.monash.edu.au

Expert Opinion on Drug Delivery
|December 22, 2007
PubMed
Summary
This summary is machine-generated.

Colloidal drug delivery systems have evolved significantly, incorporating safer materials and advanced targeting strategies. Recent biologically interactive systems mark a new era, questioning if nanotechnology will revolutionize or simply advance this field.

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Area of Science:

  • Pharmaceutical Sciences
  • Nanotechnology
  • Biomaterials

Background:

  • Colloidal drug delivery systems offer formulation solutions for challenging drug candidates.
  • These systems have historically evolved through stages like excipient improvement, PEGylation for passive targeting, and ligand conjugation for active targeting.

Purpose of the Study:

  • To review the evolutionary pathway and recent advancements in major colloidal drug delivery systems.
  • To explore the impact of the nanotechnology boom on the future of colloidal delivery.

Main Methods:

  • Literature review of colloidal drug delivery systems.
  • Analysis of historical development and recent innovations.
  • Discussion on the role of nanotechnology in the field.

Main Results:

  • Colloidal systems demonstrate a consistent evolutionary trajectory towards enhanced targeting and biocompatibility.
  • Biologically interactive systems represent a significant recent advancement.
  • The impact of nanotechnology is presented as a key question for future evolution.

Conclusions:

  • Colloidal drug delivery systems have matured significantly over decades.
  • The integration of nanotechnology may represent the next evolutionary phase rather than a complete revolution.