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Updated: Jul 9, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
Intranasal clonidine as a premedicant: three cases with unique indications
Michael J Stella1, Ann G Bailey
1Department of Anesthesiology, University of North Carolina Hospitals, Chapel Hill, NC 27599-7010, USA. mstella@aims.unc.edu
Abstract:
Clonidine is experiencing increasing use in the pediatric population as a sedative and analgesic because of its central alpha2-adrenergic agonism. We report three cases of preoperative use of intranasal clonidine in pediatric patients, all for different indications. One patient was treated for preoperative agitation and hallucinations associated with oral midazolam. One patient was given clonidine as a premedicant. The third patient was treated for preoperative agitation and hypertension. All three patients had subjective resolution of indicated symptoms and none experienced adverse outcomes.
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