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Updated: Jul 9, 2026

State of the Art Cranial Ultrasound Imaging in Neonates
10:02

State of the Art Cranial Ultrasound Imaging in Neonates

Published on: February 2, 2015

Three-dimensional sonographic evaluations of embryonic brain development.

Mi Suk Kim1, Philippe Jeanty, Cheryl Turner

  • 1Inner Vision Women's Ultrasound, Nashville, TN 37203, USA. misuksmile@gmail.com

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|December 22, 2007
PubMed
Summary

Three-dimensional (3D) sonography enables in vivo evaluation of early fetal brain ventricular development. This technique provides a crucial reference for diagnosing central nervous system anomalies in the first trimester.

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Area of Science:

  • Fetal Medicine
  • Neurosonography
  • Medical Imaging

Background:

  • Early diagnosis of central nervous system (CNS) anomalies is critical for timely intervention.
  • Standard 2D sonography has limitations in fully assessing complex fetal brain structures.
  • Three-dimensional (3D) sonography offers advanced visualization capabilities for fetal development.

Purpose of the Study:

  • To demonstrate the 3D development of fetal brain ventricles from 6 to 13 weeks of gestation.
  • To establish a reference for the early diagnosis of CNS anomalies, including hydrocephalus and holoprosencephaly.
  • To showcase the utility of 3D sonography in visualizing early embryonic brain structures.

Main Methods:

  • 46 patients underwent routine first-trimester 2D and 3D sonographic examinations.

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Last Updated: Jul 9, 2026

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  • Utilized Voluson 730 Expert or Voluson E8 ultrasound scanners with transvaginal probes (4-8 MHz or 6-12 MHz).
  • GE 4DView software with MagicCut function was employed for volume analysis and ventricular dissection.

    • Main Results:

    • Successfully dissected 34 volumes from fetuses between 7 and 12 complete gestational weeks.
    • Optimal dissection was not achieved before 7 or after 12 weeks.
    • Representative images illustrate normal ventricular development, with comparative images of ventriculomegaly and holoprosencephaly provided.

    Conclusions:

    • 3D sonography is effective for in vivo evaluation of early fetal brain ventricular structures.
    • This study provides a valuable timeline and reference images for assessing early brain development.
    • The technique aids in the identification of potential developmental anomalies during the first trimester.