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Related Experiment Video

Updated: Jul 9, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

The relationship between periodontitis and preterm low birthweight.

M V Vettore¹, M doC Leal, A T Leão

¹Department of Epidemiology and Quantitative Methods in Health, Oswaldo Cruz Foundation (ENSP/FIOCRUZ), Rua Leopoldo Bulhões, 1480-Manguinhos, Rio de Janeiro, CEP 21041-210 RJ, Brazil. mario@ensp.fiocruz.br

Journal of Dental Research

|December 22, 2007

Summary

This study found no link between periodontal disease and preterm low birthweight in women over 30. Periodontal disease was not more severe in mothers of babies with preterm low birthweight.

Related Experiment Videos

Last Updated: Jul 9, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Area of Science:

Obstetrics and Gynecology
Periodontology
Public Health

Background:

The link between periodontal disease and adverse pregnancy outcomes like preterm low birthweight remains debated.
Existing research shows conflicting results regarding the influence of periodontal disease on pregnancy complications.

Purpose of the Study:

To investigate the association between periodontal disease and preterm low birthweight.
To determine if periodontal disease severity impacts the risk of preterm low birthweight.

Main Methods:

A case-control study involving 542 postpartum women over 30 years old.
Comparison of three case groups (low birthweight, preterm, preterm and low birthweight) with a control group (non-preterm, non-low-birthweight).
Recording of periodontal clinical parameters and relevant covariates.

Main Results:

Periodontal disease levels were higher in control individuals than in case groups.
No increased risk of preterm low birthweight was associated with the extent of periodontal disease across 15 measures.
Preterm low birthweight cases exhibited lower mean periodontal pocket depth and fewer sites with clinical attachment level ≥3 mm compared to controls.

Conclusions:

Periodontal disease was not found to be more severe in women who delivered preterm low birthweight babies.
The study suggests no causal relationship between periodontal disease and preterm low birthweight in the studied population.
Further research may be needed to clarify potential complex interactions or confounding factors.