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Updated: Jan 1, 2026
A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
Published on: August 22, 2025
Classification of small contrast enhancing breast lesions in dynamic magnetic resonance imaging using a combination
Thomas Schlossbauer1, Gerda Leinsinger, Axel Wismuller
1Institute of Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany. thomas.schlossbauer@med.uni-muenchen.de
Purpose:
To evaluate the diagnostic value of breast magnetic resonance imaging (MRI) in small focal lesions using dynamic analysis based on unsupervised vector quantization in combination with a score for morphologic criteria.
Materials And Methods:
We examined 85 mammographically indetermintate lesions (BIRADS 3-4; 47 malignant, mean lesion size 1.2 cm; 38 benign, mean lesion size 1.1 cm). MRI was performed with a dynamic T1-weighted gradient echo sequence (1 precontrast and 5 postcontrast series). Lesions with an initial contrast enhancement >/=50% were selected with semiautomatic segmentation. For conventional dynamic analysis, we calculated the mean initial signal increase and postinitial course of all voxels included in a lesion. Secondly, all voxels within the lesions were assigned to 4 clusters using minimal-free-energy vector quantization. Dynamic and morphologic criteria were summarized in a diagnostic score and evaluated by receiver operating characteristic analysis.
Results:
In the present collection of small lesions, morphologic criteria [area under the curve (AUC) = 0.610] were inferior to dynamic criteria in the detection of breast cancer. Dynamic analysis with vector quantization (AUC = 0.760) presented slightly better results compared with standard dynamic analysis (AUC = 0.693). There was no benefit for combined morphologic and dynamic analysis.
Conclusion:
In small MR-mammographic lesions, dynamic analysis with vector quantization alone tends to result in a higher diagnostic accuracy compared with combined morphologic and dynamic analysis.
