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Related Experiment Videos

[Immunocorrection in rheumatoid arthritis].

A Sh Seĭsenbanov, R M Balabanova

    Terapevticheskii Arkhiv
    |January 1, 1991
    PubMed
    Summary
    This summary is machine-generated.

    This study compared immunocorrection treatments for rheumatoid arthritis. Combined prospidin and tactivin showed the best efficacy, reducing side effects and maintaining macrophage function.

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    [Evaluation of rheumatoid arthritis activity in clinical practice].

    Terapevticheskii arkhiv·2005

    Area of Science:

    • Immunology
    • Rheumatology
    • Pharmacology

    Background:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
    • Immunocorrection is a treatment approach for RA.
    • Evaluating the efficacy of different immunocorrection strategies is crucial.

    Purpose of the Study:

    • To compare the clinical and immunological effectiveness of various immunocorrection therapies in patients with rheumatoid arthritis.
    • To identify the most effective immunocorrection agents and combinations for RA treatment.

    Main Methods:

    • A study involving 125 patients with rheumatoid arthritis undergoing immunocorrection.
    • Monitoring of clinical and immunological parameters over time.
    • Comparative analysis of treatment efficacy based on drug combinations and dosages.

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    Main Results:

    • The efficacy ranking of treatments was: combined prospidin and tactivin, prospidin, high-dose immunoglobulin, combined thymohexin and low-dose immunoglobulin, thymohexin, prodigiosan, low-dose immunoglobulin.
    • Cellular immunity dynamics did not consistently correlate with clinical efficacy.
    • Reduced levels of lymphocytes expressing HLA-DR antigens indicated the most effective immunocorrection.

    Conclusions:

    • Combined prospidin and tactivin demonstrated superior efficacy in rheumatoid arthritis immunocorrection.
    • This combination also reduced side effects and preserved peripheral macrophage function.
    • Effective immunocorrection is associated with a decrease in HLA-DR expressing lymphocytes.