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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

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Published on: March 14, 2017

Febrile episodes in children with sickle cell disease treated on an ambulatory basis

S S Bakshi1, R Grover, E Cabezon

  • 1St. Luke's-Roosevelt Hospital Center, Department of Pediatrics, New York, NY 10025.

Journal of the Association for Academic Minority Physicians : the Official Publication of the Association for Academic Minority Physicians
|January 1, 1991
PubMed

Insights

Ambulatory parenteral ceftriaxone is a safe and effective alternative for managing febrile children with sickle cell disease, significantly reducing hospitalization days and preventing sepsis.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hematology

Background:

  • Children with sickle cell disease (SCD) face a high risk of severe Streptococcus pneumoniae infections.
  • Current standard care involves hospitalization and parenteral antibiotics for all febrile SCD patients.

Purpose of the Study:

  • To evaluate the safety and effectiveness of ambulatory parenteral ceftriaxone in febrile children with SCD.
  • To assess its potential to prevent sepsis and decrease hospitalization duration.

Main Methods:

  • Selected febrile children with SCD were treated with ceftriaxone on an outpatient basis.
  • Data on sepsis development and hospitalization days were compared to historical controls.

Main Results:

  • Twenty out of 40 eligible children received ambulatory ceftriaxone; 3 required subsequent hospitalization.
  • Hospitalization days decreased from 214 to 111 days compared to the previous year.

Conclusions:

  • Empiric ambulatory ceftriaxone appears safe and effective for selected febrile SCD patients.
  • Further expanded studies are needed to confirm these findings over a longer period.

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