Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The eosinophil.

R Dahl1

  • 1University Hospital of Aarlins, Aarhus, Denmark.

Allergie Et Immunologie
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Eosinophils, key immune cells, play a dual role in tissue protection and damage, particularly in parasitic infections and asthma. Their numbers and activity, especially hypodense eosinophils, are crucial indicators in disease pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: a SUNFRAIL report.

Clinical and translational allergy·2017
Same author

Work productivity in rhinitis using cell phones: The MASK pilot study.

Allergy·2017
Same author

Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

Clinical and translational allergy·2017
Same author

Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK-rhinitis study.

Allergy·2017
Same author

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle.

Clinical and translational allergy·2017
Same author

Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.

The journal of nutrition, health & aging·2016
Same journal

[The place of new antihistamines in allergy management. Apropos of desloratadine].

Allergie et immunologie·2003
Same journal

[Skin tests for trophallergens and asthma].

Allergie et immunologie·2003
Same journal

[Prevention of respiratory syncytial virus infection by SYNAGIS (palivizumab)].

Allergie et immunologie·2003
Same journal

[Compendium of specific IgE values according to professional allergists].

Allergie et immunologie·2003
Same journal

[Value of quantitative IgE measurement].

Allergie et immunologie·2003
Same journal

Capillary leakage syndrome: a case report and a review.

Allergie et immunologie·2003
See all related articles

Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Eosinophils exhibit controversial functions, acting as both protective and damaging agents in various diseases.
  • These cells are crucial in parasitic infections, correlating with IgE levels and acting as cytotoxic cells against larvae.
  • A strong link exists between asthma and eosinophils, independent of allergic factors.

Purpose of the Study:

  • To elucidate the multifaceted roles of eosinophils in health and disease.
  • To investigate the diagnostic and pathogenetic significance of eosinophil counts and subtypes.
  • To explore the impact of asthma treatments on eosinophil activity and mediator release.

Main Methods:

  • Analysis of eosinophil presence and numbers in disease states, including helminth infections and asthma.

Related Experiment Videos

  • Correlation of eosinophil counts with immunoglobulin E (IgE) titers and disease severity.
  • Examination of eosinophil heterogeneity (normodense vs. hypodense) and their functional characteristics.
  • Assessment of sputum eosinophil levels versus peripheral blood eosinophil counts.
  • Evaluation of cellular and extracellular products of eosinophils.
  • Review of treatment effects on eosinophils in asthma.

    • Main Results:

    • Eosinophils are implicated in both protective and aggressive tissue-damaging roles.
    • Elevated eosinophil numbers are observed in numerous diseases, notably helminth infections and asthma.
    • Hypodense eosinophils demonstrate higher activity, including increased secretory and chemotactic responses.
    • Sputum eosinophil analysis is more informative than blood eosinophil counts for asthma.
    • Late-phase allergic reactions involve a rise in blood eosinophils, highlighting their pathogenetic role.

    Conclusions:

    • Eosinophils are central to the pathogenesis of diseases like asthma and parasitic infections.
    • Understanding eosinophil heterogeneity and function is critical for therapeutic strategies.
    • Early consideration of eosinophil-related abnormalities is essential for effective disease management, particularly in asthma.