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[Case control study on risk factors of cerebral thrombosis]
Insights
This study identified key risk factors for cerebral thrombosis, including high blood pressure and family history. High-density lipoprotein cholesterol (HDL2-C) emerged as a protective factor against stroke.
Area of Science:
- Neurology
- Epidemiology
- Medical Research
Context:
- Cerebral thrombosis poses a significant health challenge, necessitating identification of its risk and protective factors.
- A case-control study was conducted in Jinan, Shandong Province, China, involving 110 patients diagnosed with cerebral thrombosis via computerized tomography (CT).
- Controls were meticulously matched to cases based on demographic and socioeconomic variables to ensure study validity.
Purpose:
- To investigate pathogenic risk factors and protective elements contributing to cerebral thrombosis.
- To analyze 31 potential factors using univariate and multiple stepwise regression analyses.
- To confirm significant factors through conditional logistic regression.
Summary:
- Four factors were confirmed as significantly associated with cerebral thrombosis (p < 0.01).
- High blood pressure (OR = 7.57), increased abdominal skinfold thickness (OR = 3.77), and familial aggregation of stroke (OR = 12.64) were identified as risk factors.
- Elevated levels of HDL2-C (OR = 0.16) were found to be a protective factor against cerebral thrombosis.
Impact:
- Provides crucial insights into the etiology of cerebral thrombosis, aiding in targeted prevention strategies.
- Highlights the importance of managing hypertension and obesity for stroke prevention.
- Suggests genetic predisposition and lipid profiles as critical areas for further research in stroke pathogenesis.
Abstract:
In order to explore the pathogenic risk factors or protective factors of cerebral thrombosis, 1:1 matched case control study was done in 110 cases diagnosed by computerized tomography (CT). Both cases and controls were selected from several provincial and municipal hospitals in Jinan, Shandong Province, China. Every case was matched with one control on sex, race, age, occupation, residential area, educational level and economic status. 31 factors were analysed and 9 risk or protective factors were found by univariate analysis and multiple stepwise regression. Using the same 9 factors as independent variables, conditional logistic regression was performed and 4 factors were confirmed as pathogenic risk factors or protective factor of cerebral thrombosis (alpha = 0.01). They are high blood pressure (beta = 3.46, OR = 7.57), abdominal skinfold thickness (beta = 3.21, OR = 3.77), familial aggregation of stroke (beta = 2.25, OR = 12.64) and high level HDL2-C (beta = -2.99, OR = 0.16). Moreover, reliability of collective data and control o: bias were evaluated and discussed.