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Differential leukocyte count: manual or automated, what should it be?
B H Hyun1, G L Gulati, J K Ashton
1Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
Yonsei Medical Journal
|December 1, 1991
Summary
Automated hematology analyzers for complete blood counts (CBC) and differential leukocyte counts (DLC) are increasingly vital in clinical labs. These advanced systems offer reliable CBCD results, though manual review is sometimes needed for confirmation.
Area of Science:
- Clinical laboratory science
- Hematology technology
Background:
- Automated hematology analyzers are becoming standard in clinical laboratories.
- These analyzers perform complete blood counts (CBC) and differential leukocyte counts (DLC).
Purpose of the Study:
- To assess the efficiency and reliability of modern automated hematology analyzers.
- To evaluate their performance in complete CBC with DLC (CBCD) and abnormality flagging.
Main Methods:
- Utilized automated hematology analyzers with cytochemistry, flow cytometry, laser scattering, and cell lysis technologies.
- Evaluated performance in whole blood analysis within closed tube systems.
Main Results:
- Analyzers demonstrated acceptable efficiency and reliability for CBCD.
- Flagging of significant abnormalities was found to be effective.
Conclusions:
- Automated hematology analyzers are a permanent fixture in large, quality-driven clinical laboratories.
- While reliable, selected cases may still require manual differential leukocyte count or blood smear review for confirmation.
