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Synthesis of a 3-ether analogue of lipid A
M Shiozaki1, Y Kobayashi, M Arai
1New Lead Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Carbohydrate Research
|December 30, 1991
Abstract:
Lipid A 3-ether analogues were synthesized from allyl 2-deoxy-4,6-O-isopropylidene-2-trifluoroacetamido-alpha-D-glucopyr anoside and 3,4,6-tri-O-acetyl-2-trifluoroacetamido-alpha-D-glucopyranosyl bromide. The compound lost completely the endotoxic activity.