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Interleukin-6 levels in the cerebrospinal fluid of patients with multiple sclerosis
S Araga1, H Takai, K Takahashi
1Division of Neurology, Faculty of Medicine, Tottori University, Yonago.
The Japanese Journal of Psychiatry and Neurology
|December 1, 1991
Abstract:
We developed the competitive enzyme-linked immunosorbent assay for interleukin-6 (IL-6). The detection limit was 30 pg per ml. Using this method, we examined the IL-6 levels in the cerebrospinal fluid of 10 patients with multiple sclerosis (MS) and 12 age-matched normal controls. IL-6 was detected in 6 out of 10 patients with MS. There was no significant correlation between the IL-6 levels and other parameters, including IgG, IgG index, cell counts, total protein and albumin in the CSF. Our results suggest that IL-6 detected in the MS-CSF may have no correlation to the immunological processes.