Related Experiment Video

Updated: Jul 8, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin

F S CHEEVER, J B DANIELS

    The Journal of Experimental Medicine
    |September 1, 1949
    PubMed

    Insights

    A newly isolated murine virus causes severe central nervous system disease, including myelin destruction and liver necrosis in young mice. This neurotropic virus can be transmitted via various routes and infects several rodent species.

    Area of Science:

    • Virology
    • Neuroscience
    • Pathology

    Background:

    • Disseminated encephalomyelitis is a severe neurological condition.
    • Viral infections can cause significant damage to the central nervous system and organs.

    Purpose of the Study:

    • To describe the isolation and initial characterization of a novel murine virus.
    • To investigate the pathological effects and host range of this newly identified virus.

    Main Methods:

    • Virus isolation from infected mice.
    • Inoculation studies in various animal models (mice, hamsters, rats, guinea pigs, rabbits).
    • Assessment of clinical signs and pathological changes (myelin destruction, liver necrosis).
    • Filtration studies to assess viral properties.

    Main Results:

    • A murine virus was isolated, causing disseminated encephalomyelitis and liver necrosis.
    • Infection was achieved in young mice via parenteral routes, showing encephalitic and paralytic signs.
    • The virus was detected in multiple organs post-intracerebral inoculation but not in blood.
    • Hamsters, cotton rats, and Hisaw rats were susceptible, while guinea pigs and rabbits were not.

    Conclusions:

    • A novel neurotropic virus capable of causing significant neuropathology and visceral damage has been identified in mice.
    • The virus exhibits a specific host range among rodents.
    • Further research is needed to elucidate its serological relationships and pathogenic mechanisms.
    Keywords:
    ENCEPHALOMYELITISVIRUSES

    More Related Videos

    A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus05:33

    A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

    Published on: June 23, 2022

    Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis06:19

    Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

    Published on: September 9, 2022

    Related Concept Videos

    Encephalitis ll: Pathophysiology01:26

    Encephalitis ll: Pathophysiology

    Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
    Arboviral Encephalitis01:25

    Arboviral Encephalitis

    Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
    Encephalitis l: Introduction01:19

    Encephalitis l: Introduction

    Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
    Cytomegalovirus Disease01:27

    Cytomegalovirus Disease

    Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
    Rabies01:28

    Rabies

    Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
    Bacterial Meningitis II: Pathophysiology01:26

    Bacterial Meningitis II: Pathophysiology

    Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...