Pharmacokinetics of second generation antidepressants: fluoxetine

Fluoxetine is a serotonin-specific antidepressant approved in 1987 by the Food and Drug Administration for treatment of depression. In this article, information will be reviewed concerning fluoxetine's pharmacokinetics and relation to blood levels and clinical response, to use in geriatrics, to use in medical illness, and to drug interactions.