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Related Experiment Videos

Norepinephrine effects on spinal motoneurons.

S R White1, S J Fung, C D Barnes

  • 1Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman.

Progress in Brain Research
|January 1, 1991
PubMed
Summary
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Norepinephrine (NE) application causes a slight depolarization and increased excitability in cat spinal motoneurons. This finding suggests NE generally enhances mammalian motoneuron responsiveness to excitatory input.

Area of Science:

  • Neuroscience
  • Cellular Electrophysiology

Background:

  • Norepinephrine (NE) effects on spinal motoneurons have been debated, with early reports suggesting hyperpolarization.
  • Previous studies indicated NE may reduce potassium conductance in other neuronal types.

Purpose of the Study:

  • To investigate the direct effects of NE on cat spinal motoneurons.
  • To compare NE's facilitatory effects on motoneuron excitability across species.

Main Methods:

  • Intracellular recordings from cat spinal motoneurons in situ.
  • Microiontophoretic application of NE with controlled ejection currents.

Main Results:

  • NE induced a slow, small-amplitude depolarization in cat spinal motoneurons.
  • This depolarization correlated with increased cell excitability and decreased membrane conductance.

Related Experiment Videos

  • NE's time course of action on cat motoneuron excitability matched that observed in rat spinal motoneurons.

    • Conclusions:

    • NE likely reduces potassium conductance in mammalian spinal motoneurons.
    • NE generally enhances mammalian motoneuron responsiveness to excitatory stimuli.