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Experimental intraocular tolerance to liquid perfluorooctane and perfluoropolyether
Retina (Philadelphia, Pa.)
|January 1, 1991
Summary
Perfluorinated liquids showed toxicity in rabbit eyes, causing Müller cell changes and retinal damage over two months. These perfluorinated compounds are unsuitable for long-term vitreous replacement but may be useful short-term.
Area of Science:
- Ophthalmology
- Retinal Biology
- Biomaterials Science
Background:
- Vitreous replacement is crucial for retinal detachment repair.
- Perfluorinated liquids offer potential as vitreous substitutes due to their inertness and optical properties.
Purpose of the Study:
- To evaluate the ocular tolerance of perfluorinated liquids as vitreous substitutes.
- To assess the histological effects of perfluorinated liquids on rabbit retinas over time.
Main Methods:
- Intravitreal injection of perfluorooctane and two perfluoropolyethers into rabbit eyes.
- Clinical observation and histological examination (light and electron microscopy) up to 2 months post-injection.
Main Results:
- Droplet formation observed within days of injection.
- Histological changes included Müller cell hypertrophy, retinal layer folding, photoreceptor damage, and macrophage infiltration.
- Pigment epithelial hypertrophy and drusen formation noted at 2 months, primarily in liquid-contact areas.
Conclusions:
- Perfluorinated liquids are not suitable for long-term vitreous replacement due to observed retinal toxicity.
- These liquids may have potential for short-term, intraoperative vitreous tamponade.