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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jul 8, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

[NM23 and metastasis suppressor genes: update].

Mathieu Boissan1, Marie-France Poupon, Marie-Lise Lacombe

  • 1Inserm, U680, Paris, F-75012, France.

Medecine Sciences : M/S
|December 25, 2007
PubMed
Summary

Metastasis suppressor genes, like NM23, inhibit cancer spread without affecting primary tumor growth. Epigenetic silencing of these genes offers a potential therapeutic target for controlling metastatic disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Context:

  • Metastatic dissemination is a primary cause of cancer mortality.
  • Understanding metastasis mechanisms is crucial for effective cancer treatment.
  • Metastasis suppressor genes, identified since 1988, counteract tumor spread.

Purpose:

  • To review the literature on metastasis suppressor genes.
  • To highlight the role of NM23 (NME) in suppressing metastasis.
  • To discuss the implications of epigenetic silencing and potential therapies.

Summary:

  • Metastasis suppressor genes reduce metastatic potential in vivo without inhibiting primary tumor growth.
  • These genes regulate critical signaling pathways controlling cell adhesion, invasion, and migration.

More Related Videos

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

Related Experiment Videos

Last Updated: Jul 8, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

  • Reduced expression, often due to epigenetic factors, correlates with high metastatic potential in human cancers.

    • Impact:

    • Elucidating metastasis suppressor gene function is key to developing novel anti-cancer strategies.
    • Targeting epigenetic mechanisms for re-expression of these genes presents a promising therapeutic avenue.
    • Focusing on NM23 provides insights into specific molecular players in metastasis suppression.