Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polypoid Acral Amelanotic Melanoma: A Rare Variant Treated with Wide and Deep Surgical Excision.

Acta dermatovenerologica Croatica : ADC·2026
Same author

Alopecia areata: current concepts.

Wiener klinische Wochenschrift·2026
Same author

Acral acanthotic anomaly: a comprehensive review.

Italian journal of dermatology and venereology·2026
Same author

Vincent A. Cipollaro MD (1931-2025): A Foundational Pillar in International Dermatology.

International journal of dermatology·2026
Same author

Cutaneous Amyloidosis: An Updated Approach Focusing on Macular Amyloidosis.

Dermatology (Basel, Switzerland)·2026
Same author

Keratin-TMAO dressing accelerates full-thickness skin wound healing in diabetic rats via M2-macrophage polarization and the activation of PI3K/AKT/mTOR signaling pathway.

International journal of biological macromolecules·2025

Related Experiment Video

Updated: Jul 8, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Diabetic dermopathy: A subtle sign with grave implications.

Aaron Joseph Morgan1, Robert A Schwartz

  • 1Dermatology, New Jersey Medical School, Newark, New Jersey 07103, USA.

Journal of the American Academy of Dermatology
|December 25, 2007
PubMed
Summary

Diabetic dermopathy (DD), a common skin issue in diabetes patients, signals higher risks for eye, nerve, and kidney complications. Its presence warrants early diabetes detection and proactive management to prevent severe health problems.

Related Experiment Videos

Last Updated: Jul 8, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Area of Science:

  • Dermatology
  • Endocrinology
  • Diabetology

Background:

  • Diabetic dermopathy (DD) is the most frequent skin manifestation linked to diabetes mellitus.
  • DD presents as atrophic, hyperpigmented macules, typically on the shins.

Purpose of the Study:

  • To highlight the clinical significance of diabetic dermopathy.
  • To emphasize the association of DD with microvascular complications and cardiovascular disease.

Main Methods:

  • Observational analysis of clinical presentation and patient history.
  • Literature review on diabetic dermopathy and its comorbidities.

Main Results:

  • Diabetic dermopathy is associated with neuropathy, nephropathy, and retinopathy.
  • A link between diabetic dermopathy and coronary artery disease is established.

Conclusions:

  • The identification of diabetic dermopathy necessitates prompt screening for diabetes mellitus.
  • Aggressive management is crucial to prevent or mitigate diabetes-related complications in patients with DD.