Related Experiment Video
Updated: Jul 8, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
[Current pharmacotherapies and immunotherapy in cocaine addiction]
Laurent Karila1, Aviv Weinstein, Amine Benyamina
1Université Paris-Sud, F-94276 Le Kremlin Bicêtre, France. laurent.karila@pbr.aphp.fr
Abstract:
Cocaine is more and more used and abused in France. Cocaine dependence is quite serious and is associated with numerous adverse health consequences. No effective pharmacotherapy for cocaine dependence is yet available. Recent advances in neurobiology, brain imaging and some clinical trials suggest that certain medications that modulate GABAergic, dopaminergic, and glutamatergic systems, as well as immunotherapy, show promise in the treatment of cocaine addiction. Recent controlled clinical studies have tested some of these drugs, which act on the various neurobiological circuits modified by cocaine exposure and clinically improve patients' symptoms. Pharmacological agents such as modafinil, GABAergic agents (baclofen, topiramate, tiagabin, and vigabatrin), disulfiram, aripiprazole, N-acetylcysteine and cocaine vaccine seem very promising in the treatment of cocaine dependence. However, this must be confirmed in larger patient populations.
More Related Videos
10:28Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
08:22Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference
Published on: July 30, 2013
Related Concept Videos
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Tumor Immunotherapy
Drug Therapy
Antianxiety Medications
Drug Abuse and Addiction: Pharmacological Phenomena
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...