Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses

Published on: May 3, 2016

Single dispersive gradient-index profile for the aging human lens.

José Antonio Díaz¹, Carles Pizarro, Josep Arasa

¹Departamento de Optica, Edificio Mecenas, Universidad de Granada, 18071-Granada, Spain. jadiaz@ugr.es

Journal of the Optical Society of America. A, Optics, Image Science, and Vision

|December 25, 2007

Summary

This study presents an updated age-dependent model of the human crystalline lens, incorporating a single gradient-index (GRIN) profile. The model accounts for age-related changes in refractive index, explaining variations in spherical aberration and image quality with aging.

Related Concept Videos

Focusing of Light in the Eye

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Practical method for measuring and characterizing reflective convex surfaces using Ronchi deflectometry.

Applied optics·2026

Same author

Modeling Metal(loid)s Transport in Arid Mountain Headwater Andean Basin: A WASP-Based Approach.

Water·2025

Same author

Anatomical and hemodynamic considerations are critical for preclinical models of deep vein thrombosis.

Journal of thrombosis and haemostasis : JTH·2023

Same author

"Science Gaps and Future Directions in Venous and Lymphatic Disorders": The 2022 American Venous Forum Science Program - Days of Innovation and Science (hybrid).

JVS-vascular science·2022

Same author

The 2021 American Venous Forum Day of Innovation and Science (Virtual) "Education and scientific writing in venous and lymphatic disease".

JVS-vascular science·2021

Same author

VT duets: inflammation/coagulation-wall/flow.

Blood·2021

Area of Science:

Ophthalmology
Biomedical Optics
Computational Biology

Background:

Human eye aging affects optical properties, including crystalline lens refractive index.
Age-related changes impact visual functions like spherical aberration and image quality.
Existing models often lack detailed, age-dependent crystalline lens profiles.

Purpose of the Study:

To develop an updated age-dependent emmetropic-eye model.
To incorporate a single gradient-index (GRIN) profile for the crystalline lens.
To account for age-related variations in refractive index, spherical aberration, and image quality.

Main Methods:

Developed a novel age-dependent gradient-index (GRIN) profile for the crystalline lens.
Analyzed the variation of GRIN parameters with age.

More Related Videos

Automated Compression Testing of the Ocular Lens

Automated Compression Testing of the Ocular Lens

Published on: April 5, 2024

Related Experiment Videos

Last Updated: Jul 8, 2026

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses

Published on: May 3, 2016

Automated Compression Testing of the Ocular Lens

Automated Compression Testing of the Ocular Lens

Published on: April 5, 2024

Incorporated refractive index dispersion to model ocular optical properties.

Main Results:

Dispersion parameters of the refractive index were found to be invariant with age.
Parameters defining lens index distribution showed a slight decrease in lens-center-index value with age.
The position of the lens-center-index along the lens axis changes with age.

Conclusions:

The developed GRIN profile accurately models age-related changes in the crystalline lens.
Findings support the lens paradox, explaining how lens properties change with aging.
The model provides a foundation for understanding age-related visual decline and developing corrective strategies.