Feasibility of fluid volume conductance to assess bladder volume

Ambulatory urodynamics has the potential to provide measurements of bladder function during activities of daily living; however, no method of real-time continuous bladder volume measurement exists. The present study was conducted to determine the feasibility of using fluid volume conductance to continuously assess bladder volume.

Prototype devices consisted of four electrodes mounted on a polymer body. Each was tested in an in vitro organ bath system using latex vessels filled to 500 ml with saline matching the conductivity of urine. One device was selected and used to test the effects of fluid concentration (25%, 50%, 100%, 200%, and 400% physiological saline) in latex vessels as well as the effects of fluid concentration (25%, 50%, 100%, 200%, and 400% Tyrodes solution) and temperature (32, 37, and 42 degrees C) in excised pig bladders.

Conductance demonstrated a linear increase at low volumes but approached an asymptotic value at high volumes. Conductivity increased with increased temperature or concentration. With the exception of the differences between 25% and 50% concentrations, 32 degrees C and 37 degrees C, and 37 degrees C and 42 degrees C temperatures, each concentration and temperature produced statistically different conductance measurements from all others.

The conductance method is sensitive to changes in both concentration and temperature of the intravesical solution, likely due to changes in solution conductivity. Clinical application of conductance for measurement of bladder volume will require real-time conductivity compensation for the dynamically varying properties of urine. However, improved sensitivity at high volumes is necessary before this method has the potential to provide real-time bladder volume measurement for use in ambulatory urodynamics.