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Measurement of Chitinase Activity in Biological Samples
03:32

Measurement of Chitinase Activity in Biological Samples

Published on: August 22, 2019

Serum chitotriosidase activity in patients with coronary artery disease

Bilgehan Karadag1, Mine Kucur, Ferruh K Isman

  • 1Department of Cardiology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey. karadag@istanbul.edu.tr

Circulation Journal : Official Journal of the Japanese Circulation Society
|December 27, 2007
PubMed

Insights

Serum chitotriosidase activity is elevated in patients with coronary artery disease (CAD). Higher activity levels correlate with the severity of CAD, indicating its potential as an inflammatory marker.

Area of Science:

  • Biochemistry
  • Immunology
  • Cardiovascular Medicine

Background:

  • Atherosclerosis is an inflammatory condition involving monocyte infiltration and macrophage differentiation into foam cells.
  • Chitotriosidase is a quantitative protein secreted by activated macrophages.

Purpose of the Study:

  • To investigate the association between serum chitotriosidase activity and atherosclerotic coronary artery disease (CAD).

Main Methods:

  • 200 subjects undergoing coronary angiography were analyzed.
  • Serum chitotriosidase activity was measured and correlated with CAD presence and extent.

Main Results:

  • Serum chitotriosidase activity was significantly higher in CAD patients compared to controls (p<0.001).
  • Activity levels showed a significant association with the extent of CAD, indicated by the number of diseased vessels (p<0.001).

Conclusions:

  • Serum chitotriosidase activity serves as a robust inflammatory marker for CAD.
  • Plasma chitotriosidase activity can quantitatively indicate CAD presence and disease extent.
Abstract

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