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Updated: Jul 8, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
Cancer cachexia: pathophysiologic aspects and treatment options
Erkan Topkan1, Ali Aydin Yavuz, Ozgur Ozyilkan
1Department of Radiation Oncology, Baskent University Medical Faculty, Adana Research and Treatment Centre, 01120, Adana/ Turkey. drerkantopkan@yahoo.com
Abstract:
Cancer cachexia is a syndrome characterized with progressive weight loss and abnormal wasting of fat and muscle tissue, and affects 40 to 85% of all terminally ill patients, accounting more than 20% of all cancer deaths. Current treatment for cancer cachexia principally depends on its prevention rather than reversing the present disease state, and the clinical results are far from being satisfactory. Although the exact mechanism and predisposing factors have yet to be clarified in detail, our growing knowledge about the pathophysiology and biochemical changes considering this life threatening condition should help in development of future therapeutic strategies. In the present paper, the current preclinical and clinical features considering the pathophysiology and treatment of cancer related cachexia are reviewed.
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