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Effect of a herbal psychotropic preparation, BR-16A (Mentat), on performance of mice on elevated plus-maze
1Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Abstract:
Effect of BR-16A on various parameters of anxiety and transfer latency (TL) was studied in mice using elevated plus-maze. BR-16A (50-500 mg/kg) reduced the percentage of time spent in open arms and the percent preference of open arms for the first arm entry following acute as well as chronic drug administration. The total number of arm entries and the percentage of open arm entries remained unaffected. In combination with FG 7142 (10 mg/kg), BR-16A (100-500 mg/kg) further reduced the exploration of open arms. BR-16A reversed scopolamine (0.3 mg/kg)-induced delay in TL on 1st day. The reversal effect of BR-16A was enhanced by aniracetam (50 mg/kg). The data suggest anxiogenic and nootropic actions of BR-16A.
Insights
BR-16A demonstrated anxiogenic effects by reducing open arm exploration in mice. It also showed nootropic potential by reversing scopolamine-induced memory impairment, suggesting therapeutic applications.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Anxiety disorders and cognitive impairment are significant health concerns.
- Identifying novel therapeutic agents with anxiolytic and nootropic properties is crucial.
Purpose of the Study:
- To investigate the anxiogenic and nootropic effects of BR-16A in mice.
- To evaluate the impact of BR-16A on anxiety-related behaviors and memory.
Main Methods:
- Elevated plus-maze test was used to assess anxiety-like behavior in mice.
- Transfer latency (TL) was measured to evaluate cognitive function.
- Effects of BR-16A alone and in combination with other agents (FG 7142, scopolamine, aniracetam) were studied.
Main Results:
- BR-16A (50-500 mg/kg) decreased time spent in open arms, indicating anxiogenic effects.
- BR-16A reversed scopolamine-induced delay in transfer latency, suggesting nootropic activity.
- Combined administration of BR-16A and FG 7142 further reduced open arm exploration.
Conclusions:
- BR-16A exhibits both anxiogenic and nootropic properties.
- The findings suggest BR-16A as a potential candidate for treating anxiety and cognitive deficits.