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Updated: Jul 8, 2026
A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
Published on: May 22, 2019
Persistent hypersynchronization of neocortical neurons in the mocha mutant of mouse
1Department of Neurology and Institute of Molecular Genetics, Baylor College of Medicine, Laboratory of Developmental Neurogenetics, Section of Neurophysiology, Houston, Texas 77030, USA.
Abstract:
A recessive mutation in the mouse at the mocha locus (mh, chromosome 10) modulates the synchronous synaptic activation of neocortical neurons, resulting in a constant 6-7 Hz (theta) wave pattern in the electrocorticogram. The gene-linked brain rhythm is unaffected by motor behavior and cannot be desynchronized by sensory stimuli. This exemplary neurological mutation affecting cortical excitability is the first to reveal clearly that the predominance of a specific pattern of spontaneous brain wave activity can be inherited as a recessive trait.
