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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains delta-9-tetrahydrocannabinol (THC)...

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Related Experiment Video

Updated: Jul 14, 2026

Pentylenetetrazole-Induced Kindling Mouse Model
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Published on: June 12, 2018

Psilocybin-induced behavioral and cellular effects.

Albert M Dong1, Yi Han2, Zheng Xu2

  • 1Sewickley Academy, Sewickley, PA, USA.

Journal of Neurogenetics
|July 12, 2026
PubMed
Summary

Psilocybin

Area of Science:

  • Neuroscience
  • Psychopharmacology

Background:

  • Psilocybin shows therapeutic potential for psychiatric disorders.
  • Mechanisms of psilocybin's effects are not well understood.
  • The nucleus accumbens (NAc) is crucial for reward and emotion processing.

Purpose of the Study:

  • Investigate molecular and cellular mechanisms of psilocybin in the NAc.
  • Determine the role of c-Fos expression in NAc neurons and non-neuronal cells.
  • Identify specific serotonin receptors mediating psilocybin's effects.

Main Methods:

  • Administered psilocybin (3 mg/kg) to mice.
  • Measured locomotor activity and c-Fos expression in the NAc.
  • Utilized 5-HT2A and 5-HT2B receptor antagonists (Volinanserin, RS 127445).
Keywords:
5-HT2A5-HT2BDeepLabCutPsilocybinastrocytesc-Fosdepressionnucleus accumbens

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Main Results:

  • Psilocybin transiently inhibited locomotor activity.
  • c-Fos expression peaked at different times in NAc neurons and non-neuronal cells.
  • 5-HT2A receptor inhibition affected neuronal c-Fos; 5-HT2B inhibition affected both cell types.

Conclusions:

  • c-Fos induction in NAc neurons and non-neuronal cells suggests prolonged functional changes.
  • 5-HT2B receptors and non-neuronal cells may be critical in psilocybin's mood-related effects.