Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic changes in level influence spatial coding in the lateral superior olive.

Thomas J Park1, Antje Brand, Ursula Koch

  • 1Laboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA. Tpark@uic.edu

Hearing Research
|December 29, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noise-induced reduction and early recovery of superior paraolivary nucleus sound-offset responses.

The Journal of physiology·2026
Same author

Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Longevity through immunity: the unusual naked mole-rat immune system.

GeroScience·2025
Same author

An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat.

Cancer discovery·2025
Same author

Intense low-frequency sound transiently biases human sound lateralisation.

PloS one·2025
Same author

A New Laboratory Research Model: The Damaraland Mole-rat and Its Managed Care.

Journal of the American Association for Laboratory Animal Science : JAALAS·2024
Same journal

Effects of early hearing deficits on olivocochlear efferent neuron morphology in mice.

Hearing research·2026
Same journal

Cochlear aging after synaptopathic noise: age-noise interactions in hair cell loss and axonal degeneration.

Hearing research·2026
Same journal

MERGE: Misophonia and emotion regulation in a guided experience sampling study.

Hearing research·2026
Same journal

Repopulating microglia recapitulate developmental characteristics during a period of auditory circuit recovery.

Hearing research·2026
Same journal

Deficits in tail-lift and air-righting reflexes in rats after ototoxicity associate with loss of vestibular type I hair cells.

Hearing research·2026
Same journal

Slc16a5 (MCT6) knockout induces sex-dependent changes in auditory function, hair cell viability and cochlear transcriptomic programs in the mouse.

Hearing research·2026
See all related articles

Auditory neurons adapt to preceding sounds, influencing how we perceive subsequent sounds. This study reveals that sensitivity to these ensuing stimuli is established early in the auditory pathway, specifically in the superior olivary nuclei.

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Computational Neuroscience

Background:

  • Auditory neurons exhibit adaptive responses to preceding sounds, impacting the processing of subsequent stimuli.
  • Functional roles include motion sensitivity and precedence-like effects, previously observed in the midbrain and higher auditory centers.
  • Limited knowledge exists regarding this sensitivity in the superior olivary nuclei, the initial site of binaural processing.

Purpose of the Study:

  • To investigate sensitivity to ensuing auditory stimuli at the level of the gerbil lateral superior olive.
  • To determine if binaural response properties, including interaural level difference (ILD) sensitivity, are influenced by preceding sounds.
  • To explore the earliest synaptic station for binaural processing in the auditory system.

Main Methods:

Related Experiment Videos

  • Single-cell electrophysiological recordings were performed in the gerbil lateral superior olive (LSO).
  • Responses to a designated target stimulus were measured following various preceding stimuli.
  • Analysis focused on suppression and/or enhancement of neural activity.

Main Results:

  • Contrary to expectations, a robust sensitivity to ensuing stimuli was observed in the LSO.
  • A significant majority of tested cells (86%) demonstrated substantial suppression and/or enhancement.
  • This modulation was dependent on the nature of the preceding stimulus.

Conclusions:

  • Sensitivity to ensuing auditory stimuli is established at the earliest stages of binaural processing in the superior olivary nuclei.
  • This finding challenges previous assumptions about the hierarchical processing of such effects in the auditory system.
  • The LSO plays a critical role in modulating neural responses based on auditory context from the outset.