Prenatal and postnatal development of the CGRP-immunoreactive innervation in the rat kidney

Calcitonin gene-related peptide (CGRP) immunoreactive afferent nerves were seen intrarenally by prenatal day 16. They grow rapidly and CGRP positive nerves are observed at birth associated with the arterial and venous vascular tree, forming a rich plexus in the pelvic region and in the connective tissue located near the corticomedullary region. The distribution and extent of CGRP immunoreactive nerves suggest that at birth the rat is able to provide information on the status of the kidney to be integrated in the mechanisms of body fluid homeostasis.