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Updated: Jun 19, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes
D P Potaczek1, Q-H Wang, M Sanak
1Atopy (Allergy) Research Center, Juntendo University School of Medicine, Tokyo, Japan.
Abstract:
Low-affinity IgE receptor gene (FCER2) rs3760687 polymorphism was found to be associated with differential binding affinity of transcription factors Sp1 and Sp3 leading to altered transcriptional activity. Haplotypic interaction of functional FCER2 polymorphisms (rs28364072, rs2228137 and rs3760687) might potentially provide a background for genotype-phenotype associations previously observed for some rather non-functional FCER2 variants.
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