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Elevated soluble CD30 characterizes patients with hepatitis C virus-induced liver allograft cirrhosis

Ankit Bharat1, Kishore Narayanan, Anjali Golocheikine

  • 1Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

Transplantation
|January 1, 2008
PubMed

Insights

Hepatitis C virus recurrence post-transplant accelerates cirrhosis. A lack of Th1 immunity and elevated soluble CD30 (sCD30) indicate higher cirrhosis risk in liver transplant patients.

Area of Science:

  • Immunology
  • Hepatology
  • Transplantation

Background:

  • Hepatitis C virus (HCV) recurrence post-orthotopic liver transplantation (OLT) accelerates allograft cirrhosis.
  • Current biochemical markers for monitoring HCV progression lack specificity and sensitivity.

Purpose of the Study:

  • Investigate HCV-specific immunity (T-helper cell responses) and serum soluble CD30 (sCD30) levels.
  • Determine association between immune profiles, sCD30, and allograft cirrhosis in OLT recipients.

Main Methods:

  • Compared HCV-specific CD4 T(h1) (IFN-gamma) and T(h2) (IL-5) cell frequencies in patients with and without allograft cirrhosis.
  • Measured serum levels of soluble CD30 (sCD30) in both patient groups.

Main Results:

  • Patients with hepatic inflammation but no cirrhosis (HIN) showed higher interferon (IFN)-gamma and T(h1) cells.
  • Patients with hepatic cirrhosis (HFC) exhibited higher interleukin (IL)-5 and T(h2) cells.
  • Significantly elevated sCD30 levels were observed in HFC patients compared to HIN patients.

Conclusions:

  • A deficiency in Th1-type CD4 T cell responses is linked to HCV-induced allograft cirrhosis.
  • Serum sCD30 may serve as a novel biomarker for monitoring hepatic cirrhosis in HCV-infected liver transplant recipients.

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