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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: Jul 8, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Stem cells and breast cancer.

M Cariati1, A D Purushotham

  • 1Department of Academic Oncology, King's College London, Guy's Hospital, London, UK.

Histopathology
|January 4, 2008
PubMed
Summary

Normal mammary stem cells and cancer stem cells are key to understanding breast cancer. Identifying and targeting these cells could revolutionize future cancer treatments.

Area of Science:

  • Stem cell biology
  • Oncology
  • Mammary gland development

Background:

  • Continuously renewing tissues, like the mammary gland, exhibit hierarchical proliferation organized by stem cells and transit-amplifying cells.
  • Mammary stem cells have been identified and purified using surface antigen expression.
  • The identification of mammary epithelial stem cells has led to the hypothesis linking them to breast cancer origins.

Purpose of the Study:

  • To review the evidence supporting the existence of normal mammary stem cells.
  • To review the evidence supporting the existence of breast cancer stem cells.
  • To explore the implications of cancer stem cells for future epithelial cancer treatment strategies.

Main Methods:

  • Review of existing scientific literature on mammary stem cells and cancer stem cells.

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Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines
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Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines

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Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
08:39

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

Related Experiment Videos

Last Updated: Jul 8, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines
10:51

Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines

Published on: March 22, 2015

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
08:39

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

  • Analysis of studies identifying and characterizing mammary stem cells.
  • Examination of research on cancer stem cells in breast cancer samples and cell lines.

    • Main Results:

    • Evidence supports the existence of both normal mammary stem cells and highly tumorigenic cancer stem cells in breast cancer.
    • Cancer stem cells, a small subpopulation, are responsible for tumor proliferation and metastasis.
    • The identification of cancer stem cells offers a new perspective on tumor heterogeneity.

    Conclusions:

    • The existence of cancer stem cells provides a biological basis for tumor growth and spread.
    • Understanding and targeting cancer stem cells may lead to more effective future treatments for epithelial cancers.
    • This research highlights the importance of stem cell populations in both normal tissue regeneration and cancer development.