Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Building a Parallel Metabolism within the Cell.

Aleksandra Filipovska1, Oliver Rackham

  • 1‡ School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia, Australia † Western Australian Institute for Medical Research and Centre for Medical Research, University of Western Australia, Perth, Western Australia, Australia, rackham@waimr.uwa.edu.au.

ACS Chemical Biology
|January 5, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Specific SLC25 carriers regulate mitochondrial protein synthesis.

Science advances·2026
Same author

POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels.

Life science alliance·2025
Same author

Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle.

Nature communications·2025
Same author

The Vsr-like protein FASTKD4 regulates the stability and polyadenylation of the MT-ND3 mRNA.

Nucleic acids research·2024
Same author

Hyperactive Nickase Activity Improves Adenine Base Editing.

ACS synthetic biology·2024
Same author

Interorganelle phospholipid communication, a house not so divided.

Trends in endocrinology and metabolism: TEM·2024
Same journal

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation Domain.

ACS chemical biology·2026
Same journal

Development of Next-Generation Fluoroacetamidine-Containing Activity-Based Probes for the Selective Labeling of the Protein Arginine Deiminases (PADs).

ACS chemical biology·2026
Same journal

Spectroelectrochemical Insight into Reaction Mechanisms of Cell-Penetrating Peptides on Charged Membrane Surfaces.

ACS chemical biology·2026
Same journal

Metal- and Redox-Dependent Oxytocin Species Differentially Regulate Invasion and Migration in Triple-Negative Breast Cancer.

ACS chemical biology·2026
Same journal

A Systematic Direct-to-Biology Approach Identified Potent Cereblon HaloPROTACs.

ACS chemical biology·2026
Same journal

Resistance-CONKAT-seq Guided Discovery of a ClpP Active Natural Product from a Soil Metagenome.

ACS chemical biology·2026
See all related articles

Synthetic biology engineers artificial cellular processes using an orthogonal approach. This creates parallel metabolic pathways for predictable component interactions, enabling novel cell functions.

Area of Science:

  • Synthetic Biology
  • Cellular Engineering
  • Metabolic Engineering

Background:

  • Engineering artificial cellular processes requires predictable component interactions.
  • Existing cellular molecules are often constrained by native cellular functions and health maintenance.
  • A key challenge is to create cellular systems independent of native biological constraints.

Purpose of the Study:

  • To explore the orthogonal approach for engineering artificial cellular processes.
  • To overcome limitations imposed by native cellular environments.
  • To enable the development of novel cellular functions and applications.

Main Methods:

  • Designing and implementing parallel metabolic pathways within cells.
  • Sourcing components from evolutionarily distant species.

Related Experiment Videos

  • Reengineering existing cellular molecules using rational design and directed evolution.

    • Main Results:

    • Demonstrated the feasibility of creating orthogonal metabolic pathways.
    • Showcased the ability of engineered components to function predictably.
    • Established a foundation for cells with novel functionalities.

    Conclusions:

    • The orthogonal approach is a viable strategy for synthetic biology.
    • Engineered parallel metabolisms allow for predictable cellular component interactions.
    • This approach facilitates the creation of advanced cellular applications such as sensors, computers, and drug factories.