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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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Related Experiment Video

Updated: Jul 8, 2026

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

Why is the developed world obese?

Sara Bleich1, David Cutler, Christopher Murray

  • 1Department of Health Policy and Management, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA. sbleich@jhsph.edu

Annual Review of Public Health
|January 5, 2008
PubMed
Summary
This summary is machine-generated.

Rising obesity is mainly due to increased calorie consumption, not reduced physical activity. Technological and sociodemographic factors contribute to this dietary excess, informing future obesity research and policy.

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Last Updated: Jul 8, 2026

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
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Published on: November 1, 2019

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Published on: May 30, 2025

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
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Published on: November 11, 2025

Area of Science:

  • Public Health
  • Nutrition Science
  • Epidemiology

Background:

  • Global obesity rates have significantly increased over recent decades.
  • The precise drivers of this epidemic, specifically the balance between energy intake and expenditure, remain unclear.
  • The influence of socioeconomic factors on energy balance and obesity is not well understood.

Purpose of the Study:

  • To estimate the relative contributions of increased caloric intake versus reduced physical activity to obesity in developed nations.
  • To explore the technological and sociodemographic determinants linked to excessive caloric consumption.
  • To provide insights for future research on the causes of obesity.

Main Methods:

  • Employed two distinct methods of energy accounting for analysis.
  • Utilized multivariate regression models to assess contributing factors.
  • Conducted simulation analysis to investigate determinants of dietary excess.

Main Results:

  • The primary driver of rising obesity is identified as increased calorie consumption.
  • Higher caloric intake is significantly associated with technological advancements.
  • Changes in sociodemographic factors also correlate with increased caloric intake.

Conclusions:

  • Obesity trends are predominantly influenced by dietary changes rather than energy expenditure.
  • Technological innovations and evolving sociodemographics play a role in increased caloric intake.
  • Future public health policies should prioritize strategies to reduce caloric consumption.