Related Experiment Video

Updated: Jul 8, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

MTA family of coregulators in nuclear receptor biology and pathology

Bramanandam Manavathi1, Kamini Singh, Rakesh Kumar

  • 1Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

Nuclear Receptor Signaling
|January 5, 2008
PubMed

Insights

Metastasis-associated proteins (MTA) are novel nuclear receptor (NR) coregulators. They generally repress gene transcription but can act as coactivators, impacting NR signaling and disease.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Biology

Background:

  • Nuclear receptors (NRs) regulate gene transcription via coactivators and corepressors.
  • Metastasis-associated proteins (MTA) are emerging NR coregulators.
  • MTA proteins, particularly MTA1, play complex roles in gene transcription.

Purpose of the Study:

  • To highlight the function of MTA proteins in nuclear receptor (NR) signaling.
  • To discuss the roles of MTA proteins in various pathophysiological conditions.
  • To review the dual role of MTA1 as a repressor and coactivator.

Main Methods:

  • Literature review of studies on MTA proteins and NR signaling.
  • Analysis of MTA protein interactions with nucleosome remodeling complexes.
  • Examination of MTA protein roles in gene transcription regulation.

Main Results:

  • MTA proteins generally form NuRD complexes to repress gene transcription.
  • MTA1 can act as a coactivator in a promoter-context dependent manner.
  • MTA1, MTA1s, and MTA2 repress estrogen receptor activity, while estrogen signaling regulates MTA3.

Conclusions:

  • MTA proteins are significant modulators of NR signaling.
  • Dysregulation of MTA proteins is implicated in pathophysiological states.
  • Understanding MTA protein functions is crucial for NR-targeted therapies.

More Related Videos

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation09:07

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes07:55

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...