[Validation the haplotype polymorphisms of the DXS7424-DXS101 on X-chromosome]
Bing Yu1, Ya Tuo, Hong-sheng Gui
1Key Laboratory of Forensic Sciences, National Ministry of Health, Xi'an Jiaotong University, Xi'an, 710061 China. yubing@mail.xjtu.edu.cn
Objective:
To validate the genetic characteristics and distribution of DXS7424-DXS101 on X chromosome in Han population.
Methods:
DXS7424 and DXS101 loci were genotyped by PCR, PAGE and silvers stain methods. Their genetic parameters were analyzed by Arlequin software.
Results:
There were 37 haplotypes detected in 151 Han unrelated males. The frequencies ranged from 0.0066 to 0.1391, with a GD value of 0.9453 and a DP value of 0.9389. Haplotypes 16-23 were the most common haplotypes in Han population.
Conclusion:
Analysis of combined DXS7424 and DXS101 haplotypes appears to be a powerful means in population genetics and forensic practice for determination of identity and paternity.
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