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Electret enhances transdermal drug permeation.

Narasimha Sathyanarayana Narasimha Sathyanarayana Murthy1, Vishwanath Anantharamaiah Boguda, Kotrappa Payasada

  • 1Department of Pharmaceutics, The University of Mississippi, MS 38677, U.S.A. murthy@olemiss.edu

Biological & Pharmaceutical Bulletin
|January 8, 2008
PubMed
Summary

Electret discs enhance skin permeability for polar molecules like salicylic acid but reduce it for lipophilic ones. This effect depends on electret voltage but not charge polarity, impacting transdermal drug delivery potential.

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Area of Science:

  • Materials Science
  • Biophysics
  • Dermatology

Background:

  • Electrets are charged polymeric discs generating electrostatic potentials (500-3,000 V).
  • Skin permeability is a critical factor in transdermal drug delivery.
  • Understanding factors influencing skin barrier function is essential for therapeutic applications.

Purpose of the Study:

  • To investigate the effect of electret exposure on skin permeability.
  • To evaluate electret-mediated enhancement of transdermal transport for different molecules.
  • To elucidate the mechanism underlying electret-induced changes in skin barrier properties.

Main Methods:

  • Transdermal transport studies using porcine epidermis in Franz diffusion cells.
  • In vivo studies in Sprague Dawley rats to assess salicylic acid permeation.
  • Utilized salicylic acid, fluorescein labeled dextrans (FD, 1 kDa), and propofol as model diffusants.

Main Results:

  • Electret exposure significantly enhanced the transdermal permeation of salicylic acid.
  • Enhancement increased with electret surface voltage, independent of charge polarity (+/-).
  • Electret-mediated enhancement was size-dependent, with a cut-off around 1 kDa for FD.
  • Conversely, electrets decreased skin permeability to the lipophilic molecule propofol.
  • Electret pretreatment enhanced iontophoretic transport but not electroporation of salicylic acid.

Conclusions:

  • Electret exposure alters stratum corneum lipid domains, increasing permeability to polar molecules.
  • This mechanism explains the enhanced transport of salicylic acid and reduced transport of propofol.
  • Electrets show potential for modulating skin permeability, influencing transdermal delivery of polar and nonpolar compounds.