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The hypoglycemic effect of "Hipogalegin"
Revue Roumaine De Physiologie (Bucharest, Romania : 1990)
|January 1, 1991
Summary
Hipogalegin significantly reduced blood glucose in diabetic rats, with 40% surviving 94 days post-treatment. Untreated diabetic rats died within two weeks, highlighting Hipogalegin
Area of Science:
- Pharmacology
- Diabetology
- Animal Models
Background:
- Alloxan-induced diabetes in rats is characterized by significantly elevated fasting blood glucose levels.
- Diabetic complications often lead to mortality within a short period if left untreated.
Purpose of the Study:
- To evaluate the efficacy of "Hipogalegin" in managing hyperglycemia in a rat model of diabetes.
- To assess the survival rate of diabetic rats treated with "Hipogalegin" compared to untreated controls.
Main Methods:
- Diabetes was induced in rats using alloxan.
- A single dose of "Hipogalegin" (0.45 g/kg body weight) was administered to diabetic rats.
- Fasting glycemia and survival rates were monitored over 94 days.
Main Results:
- "Hipogalegin" administration resulted in a marked decrease in fasting glycemia in diabetic rats.
- 40% of the treated diabetic rats survived until day 94 post-induction.
- All untreated diabetic rats died within the first two weeks.
Conclusions:
- "Hipogalegin" demonstrates significant hypoglycemic effects in alloxan-induced diabetic rats.
- "Hipogalegin" treatment markedly improves survival rates in diabetic rats.