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Development and validation of GC-MS method for the determination of methyl methanesulfonate and ethyl

K Ramakrishna1, N V V S S Raman, K M V Narayana Rao

  • 1College of Science, GITAM University, Visakhapatnam 530045, India. karipeddi_rk@yahoo.com

Journal of Pharmaceutical and Biomedical Analysis
|January 8, 2008
PubMed

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Gas Chromatography–Mass Spectrometry (GC–MS)01:14

Gas Chromatography–Mass Spectrometry (GC–MS)

Gas chromatography–mass spectrometry (GC–MS) is the combination of analytical techniques of gas chromatography and mass spectrometry in a single instrument for analyzing a mixture of compounds. The gas chromatograph separates the compounds in the mixture, and the mass spectrometer analyzes each compound separately to determine the molecular masses and molecular structures.
A gas chromatograph consists of a long, narrow capillary column with a polysiloxane coating on the inner wall. The coating...